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KMID : 1234920170170020087
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Journal of Korean Oriental Association for Study of Obesity
2017 Volume.17 No. 2 p.87 ~ p.95
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A 8-Week, Randomized, Double-Blind, Placebo-Controlled Human Trial to Evaluate the Efficacy and Safety of Punica granatum L.ㆍ Actinidia chinensis Planch. Mixed Extract on Body Fat
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Choi Jin-Bong
Lee Ji-Eun
Do Yun-Kyoung
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Abstract
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Objectives: This study was conducted to evaluate efficacy and safety of Punica granatum L.ㆍActinidia chinensis Planch. mixed extract on body fat.
Methods: Thirty women were recruited (25 kg/m2≤body mass index [BMI]≤29.9 kg/m2) (19 yr≤ age≤38 yr) and randomized to receive Punica granatum L.ㆍActinidia chinensis Planch. mixed extract or placebo for 8 weeks. During the test, they visited four times including screening. Body fat mass, body fat rate, anthropometric dimensions at waist and hip, waist-hip ratio, total cholesterol, triglyceride, low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C) were measured at screening and 8 weeks after screening. Adverse reaction were also checked each visit.
Results; There were no significant differences in all index. But when divide experimental group by BMI index, age, and compliance, less than BMI 27 kg/m2 group decreased body weight, body fat mass and more than BMI 27 kg/m2 group also decreased body weight, body fat mass and waist circumference. Less than age 30 years group showed decline of waist circumference, fat free rate and T-cholesterol and more than age 30 years group showed decline of fat free mass. Group with compliance more than 95% was decreased BMI, fat free mass, and hip circumference.
Conclusions; There was no significant efficacy as compared with placebo group, but as divide experimental group according to BMI index, age, compliance, mixed extract might be effective to reduce obesity index.
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KEYWORD
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Punica granatum L, Actinidia chinensis Planch, Obesity, Randomized controlled trial
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